8/26/2023 0 Comments Annan retina eye centerThe retinal vessel volume-rendering showed the altered microcirculation in the macula, for example in fovea plana, which is important because these eyes cannot fit into the scheme of normative data banks offered by the commercial manufacturers 16.Īlthough the information obtained from OCTA is three dimensional, a compromise between the amount of information and the display capabilities 17, 18, 19, 20 was made by condensing the extracted information to a one-pixel thick planar view of selected layers which is currently used as the standard display method 21, 22. In addition to magnetic resonance imaging, OCT and OCTA have emerged as beneficial imaging tools in multiple sclerosis 15. Furthermore, OCT and OCTA were applied in the diagnosis, monitoring, and indications for therapeutic interventions in age-related macular degeneration 12, 13, which might affect more than 20% of the aging population 14. ![]() Consequently, OCTA has evolved into a fast, safe, and frequently used ophthalmic imaging technology 8 that demonstrates great promise in terms of improving our understanding of the physiology and pathophysiology of the eye 6.įor example, in diabetic retinopathy, OCTA provided capillary perfusion density maps for the quantification of the deep capillary layers, which aided in documenting disease progression and in assessing risk stratification 9, 10, 11. In this context, optical coherence tomography angiography (OCTA) has been successfully introduced as a depth resolved imaging technique that displays the movement of blood within the vessels with the help of intrinsic signals 4, 5, 6 and without the need for a dye injection 7. Thus, the fact of the matter is FA does not adequately image retinal blood flow. In addition, fluorescein angiography does not show the radial peripapillary capillary network, the intermediate capillary plexus or the deep capillary plexus 4. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.įor decades, fluorescein angiography (FA) has been the gold standard for retinal vessel imaging 1 despite the fact that it is an invasive 2, 3 and time-consuming procedure that causes mild to severe adverse reactions. No significant correlations were found for sex or between left and right eyes. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. OCTA vessel surface area was slightly negatively correlated with age. The mean overall vessel surface area was 54.53 mm 2 (range from 27.03 to 88.7 mm 2). A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. ![]() Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina.
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